Is Multivariate GWAS a GWAS with multiple phenotypes at once? What is the exact definition?
In simple terms, what is the output/result of Multivariate GWAS? Variants associated with several traits at once…?
Replying to “Is Multivariate GWAS a GWAS with multiple phenotyp…”:
It depends on the model - there is no single definition of a multivariate gwas model. You could estimate the SNP associations with a common factor underlying multiple traits, or you could estimate SNP associations with one trait, conditional on another (like gwas-by-subtraction). There can be numerous types of “multivariate” GWAS, accounting for the relationship between multiple traits