does sample size matter in LDsc regression. I mean can use GWAS with samples less than 1000 for LDsc?
Yes, not advised for samples less than 5k.
Replying to “does sample size matter in LDsc regression. I mean…”:
your GWAS needs to have some strong signals for it work well - so 10000 might not be enough if there is low signal
Replying to “does sample size matter in LDsc regression. I mean…”:
Ordinarily for genomic SEM you would want to include traits where the heritability Z-statistic is >4 to ensure the results are stable for modelling and that would tend to be in samples >5k ideally 10k
Replying to “does sample size matter in LDsc regression. I mean…”:
Are referring to the number of snps or number of individuals used to generate the GWAS?
Replying to “does sample size matter in LDsc regression. I mean…”:
people
Replying to “does sample size matter in LDsc regression. I mean…”:
right. thank you
Replying to “does sample size matter in LDsc regression. I mean…”:
Isabelle said it better - be guided by the heritability Z