what is generally considered a good sample size for a PGS target sample population?
Replying to “what is generally considered a good sample size fo…”:
depends on the heritability of the trait and sample size of the GWAS
Replying to “what is generally considered a good sample size fo…”:
As big as possible - you can check power using a standard regression power calculator
Replying to “what is generally considered a good sample size fo…”:
Can rare variants included in PRS analysis increase the prediction accuracy of the trait?
Replying to “what is generally considered a good sample size fo…”:
technically yes - in practice it depends on how rare they are
Replying to “what is generally considered a good sample size fo…”:
it should, but methods require LD reference data, which should then also include the rare variants
Replying to “what is generally considered a good sample size fo…”:
also keep in mind that rare variants, by virtue of being rare, are probably not going to explain much variance in the sample