Running Genomic SEM Locally

meaning we can’t run this locally on our computers?

Replying to “meaning we can’t run this locally on our computers…”:

with the new version you will be able to

Replying to “meaning we can’t run this locally on our computers…”:

as of this week we can: https://www.biorxiv.org/content/10.64898/2026.06.03.729606v1.abstract

Replying to “meaning we can’t run this locally on our computers…”:

check your available (storage) memory before you start

Replying to “meaning we can’t run this locally on our computers…”:

much is required?

Replying to “meaning we can’t run this locally on our computers…”:

1 set of GWAS sumstats run on the 1kgp references is generally ~2GB pre QC

Replying to “meaning we can’t run this locally on our computers…”:

after QC ~.5GB as your base data

Replying to “meaning we can’t run this locally on our computers…”:

for comparision HapMap2 =2.4M snps, HapMap3 =1.3, 1kgp=24M, HRC=44M, TopMed=240M BUT across all after QC only around 8-12M survive MAF and r2 QC