If I generate summary statistics for a set of traits from my own individual-level genetic data, can gemonicSME applied to this set of traits with almost 100% sample overlap?
Replying to “If I generate summary statistics for a set of trai…”:
Yes — the V matrix will have very high off-diagonal numbers, but that means it’s appropriately correcting for the sample overlap! (In other words, lots of genomic SEM is done on a bunch of traits from the UK biobank)
Replying to “If I generate summary statistics for a set of trai…”:
This is a great example! Thank you, Ted