how do we model environmental effects or gene–environment interactions in the QTL analyses, it is the same as looking into key covariates such as age, sex, ancestry principal components , thank
Replying to “how do we model environmental effects or gene–envi…”:
Great question and it depends - conditioning on heritable covariates can cause some challenges in the genetic associations - see this paper: Adjusting for heritable covariates can bias effect estimates in genome-wide association studies - PubMed
Replying to “how do we model environmental effects or gene–envi…”:
Thanks a ton.
Replying to “how do we model environmental effects or gene–envi…”:
Otherwise, it depends a lot on the modeling question