Hi, All,
I would like to make a note of when it is necessary to remove palindromic SNPs from analyses downstream of GWAS. For these analyses, the effect allele and reference alleles are always annotated.
It seems it is not necessary to remove them from FUMA analyses.
PRScs seems to automatically remove them in its current version.
Should they be removed from Mendelian Randomization analyses?
Thank you for advising.
Jamee