Hi! sorry if this is basic but what is the difference or relation between missing heritability and non-transmitted alleles? Is it that the non-transmitted alleles contribute to missing heritability or are they completely unrelated?
Thank you!
Hi! sorry if this is basic but what is the difference or relation between missing heritability and non-transmitted alleles? Is it that the non-transmitted alleles contribute to missing heritability or are they completely unrelated?
Thank you!
They’re essentially unrelated concepts - with this exception. The correlation between PGSs built from non-transmitted alleles and the offspring phenotype is an approach for assessing “genetic nurture,” which is equivalent to what in BG-land we call “passive gene-environment correlation.” So to the degree you’re asking whether passive G-E correlation is related to missing h2, yes, there is a relationship b/c passive G-E correlation will have different influences on h2 estimation depending on the design. For twin studies, it will inflate estimates of V(C) (common environment variance). For SNP-heritability studies, it will inflate estimates of SNP-h2. In GWAS, it inflates estimates of r2.
BTW, we should differentiate different types of missing h2:
missing h2 = the difference between the sum of r2 from GWAS hits and twin h2
still-missing h2 = difference between SNP-h2 and twin h2
hidden h2 = difference between sum of r2 and SNP-h2
I’m wondering if your question is really about the still-missing h2 (?).