# X Chromosome Inactivation

**URL:** https://isgw-forum.colorado.edu/t/x-chromosome-inactivation/494
**Category:** Common & rare variant association
**Created:** [March 6, 2023, 11:51pm UTC](https://isgw-forum.colorado.edu/t/x-chromosome-inactivation/494 "2023-03-06T23:51:24Z")
**Posts on this page:** 2
**Page:** 1

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### Author: ![aleaalbright](https://isgw-forum.colorado.edu/letter_avatar_proxy/v4/letter/a/7993a0/32.png) [@aleaalbright](https://isgw-forum.colorado.edu/u/aleaalbright)
#### Post date: [March 6, 2023, 11:51pm UTC](https://isgw-forum.colorado.edu/t/x-chromosome-inactivation/494/1 "2023-03-06T23:51:24Z")

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Hi! Out of curiosity–I’ve heard that one thing that has made inclusion of the X chromosome so difficult in GWAS/downstream analyses has been X chromosome inactivation. Does anyone know what’s the status on this? Has this problem been solved/figured out?

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### Author: ![levans](https://isgw-forum.colorado.edu/letter_avatar_proxy/v4/letter/l/5f8ce5/32.png) [@levans](https://isgw-forum.colorado.edu/u/levans)
#### Post date: [March 7, 2023, 5:43am UTC](https://isgw-forum.colorado.edu/t/x-chromosome-inactivation/494/2 "2023-03-07T05:43:51Z")

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here’s a nice review that goes over the issue and some of the approaches for handling it:

> **[systematic review of analytical methods used in genetic association analysis...](https://academic.oup.com/bib/article/23/5/bbac287/6651325)**
>
> Abstract. Genetic association studies have been very successful at elucidating the genetic background of many complex diseases/traits. However, the X-chromosome