# Sample Overlap in LDSC

**URL:** <https://isgw-forum.colorado.edu/t/sample-overlap-in-ldsc/890>\
**Category:** Day 6\
**Created:** [June 10, 2026, 2:27pm UTC](https://isgw-forum.colorado.edu/t/sample-overlap-in-ldsc/890 "2026-06-10T14:27:53Z")\
**Posts on this page:** 1\
**Page:** 1

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**Author:** ![anonymous](https://isgw-forum.colorado.edu/letter_avatar_proxy/v4/letter/a/8491ac/32.png) [@anonymous](https://isgw-forum.colorado.edu/u/anonymous)\
**Post date:** [June 10, 2026, 2:27pm UTC](https://isgw-forum.colorado.edu/t/sample-overlap-in-ldsc/890/1 "2026-06-10T14:27:53Z")

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If they’re not independent samples for LDSC, could there be bias from sample overlap?

> Replying to “If they’re not independent samples for LDSC, could…”:

Sample overlap only bias the intercept. The slope of the regression, which is used to calculate genetic correlation, is unbiased of sample overlap