# Bottoms Up vs Top Down GWAS

**URL:** <https://isgw-forum.colorado.edu/t/bottoms-up-vs-top-down-gwas/528>\
**Category:** Downstream analysis with genomic data\
**Created:** [March 10, 2023, 10:54pm UTC](https://isgw-forum.colorado.edu/t/bottoms-up-vs-top-down-gwas/528 "2023-03-10T22:54:21Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![JD3874](https://isgw-forum.colorado.edu/user_avatar/isgw-forum.colorado.edu/jd3874/32/44_2.png) [@JD3874](https://isgw-forum.colorado.edu/u/JD3874)\
**Post date:** [March 10, 2023, 10:54pm UTC](https://isgw-forum.colorado.edu/t/bottoms-up-vs-top-down-gwas/528/1 "2023-03-10T22:54:22Z")

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![replication](https://isgw-forum.colorado.edu/uploads/default/original/1X/e03976a2bac5d7f9891f76ab3c313014a3d1bd59.jpeg)

We talked about the the issues behind not being able to replicate GWAS results, issues with linkage disequilibrium, etc.

Is it possible to bypass LD and improve replication accuracy by performing GWAS or a variation of GWAS at the individual and family level…and then community level (for statistical power) to get past these limitations?

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**Author:** ![JD3874](https://isgw-forum.colorado.edu/user_avatar/isgw-forum.colorado.edu/jd3874/32/44_2.png) [@JD3874](https://isgw-forum.colorado.edu/u/JD3874)\
**Post date:** [March 10, 2023, 11:47pm UTC](https://isgw-forum.colorado.edu/t/bottoms-up-vs-top-down-gwas/528/2 "2023-03-10T23:47:30Z")

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Matthew Keller just answered this…